Alpha-keto Acid Dehydrogenase Complexes PDF ePub eBook

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Alpha-keto Acid Dehydrogenase Complexes free pdf Found in all organisms, the alpha-keto acid dehydrogenase complexes have central roles in cellular metabolism and are major sites of regulation. The understanding of the organization, funtion and regulation of these multi-enzyme complexes has been advanced by studies employing molecular biology and biophysical techniques. Although these enzyme systems have some features in common, there is much diversity in fulfilling unique organism- or tissue-specific roles. These systems have medical importance in areas ranging from defects in regulation (linked to diabetes, heart disease, obesity, nutrition defects), to inherited diseases (in-born errors, maple syrup urine disease) to acquired immune diseases (primary biliary cirrhosis). This text brings together findings on the structure-function relationships, and genetic defects of the alpha-keto acid dehydrogenase complexes, namely the pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase and the branched-chain alpha-keto acid dehydrogenase complexes. A variety of experimental approaches together with results presented in this book should serve as a resource for beginning to established investigators in the field, as well as scientists who are interested in mitochondria, dehydrogenases, kinases, phosphatases, lipoic acid, thiamine pyrophosphate, and enzyme complexes.

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Details Book

Author : M.S. Patel
Publisher : Birkhauser Verlag AG
Data Published : 01 January 1996
ISBN : 3764351810
EAN : 9783764351816
Format Book : PDF, Epub, DOCx, TXT
Number of Pages : 321 pages
Age + : 15 years
Language : English
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    Books Download ePub. Found in all organisms, the alpha-keto acid dehydrogenase complexes have central roles in cellular metabolism and are major sites of regulation. The understanding of the organizat