Analyzing Biomolecular Interactions by Mass Spectrometry PDF ePub eBook

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Analyzing Biomolecular Interactions by Mass Spectrometry free pdf This monograph reviews all relevant technologies based on mass spectrometry that are used to study or screen biological interactions in general. Arranged in three parts, the text begins by reviewing techniques nowadays almost considered classical, such as affinity chromatography and ultrafiltration, as well as the latest techniques. The second part focusses on all MS-based methods for the study of interactions of proteins with all classes of biomolecules. Besides pull down-based approaches, this section also emphasizes the use of ion mobility MS, capture-compound approaches, chemical proteomics and interactomics. The third and final part discusses other important technologies frequently employed in interaction studies, such as biosensors and microarrays. For pharmaceutical, analytical, protein, environmental and biochemists, as well as those working in pharmaceutical and analytical laboratories.

About Jeroen Kool

Jeroen Kool focussed in his PhD study on the integration of chemical and biochemical detection after separation methodologies. Following his PhD, he was responsible for target evaluation, hit screening and identification, and lead optimization processes at Kiadis Pharma (The Netherlands). He continued his academic career in 2005 as a post-doc in the Biomolecular Mass Spectrometry group in Utrecht working on proteomics and biomarker discovery. From 2007 to present, he is responsible for the research line Bioanalytical Screening Methodologies at the VU University Amsterdam (The Netherlands) with a particular focus on hyphenated analytical techniques combining mass spectrometry and chromatography with novel bioassay techniques for bioactive mixture analysis. He published over 40 peer reviewed articles and one book chapter. Wilfried Niessen studied chemistry at the VU University of Amsterdam. After his PhD, he worked for 9 years as an analytical chemist within the Leiden/Amsterdam Center for Drug Research at Leiden University (The Netherlands). After leaving the university in 1996, he started the company hyphen MassSpec, providing independent consultancy and training in the field of analytical mass spectrometry. In parallel to his consultant activities, he was appointed extraordinary professor in bioanalytical mass spectrometry at the Faculty of Science of the VU University in Amsterdam in 2002. He is currently Interim Head of the Division BioMolecular Analysis and Spectroscopy at VU University Amsterdam. His main research interests involve principles, instrumentation and applications of liquid chromatography-mass spectrometry as well as interpretation of small-molecule MS/MS mass spectra. He is (co)author of more than 180 publications in the field of LC-MS in refereed international journals and more than 30 book chapters. Wilfried Niessen authored and edited five books, and was guest editor on several special journal issues.

Details Book

Author : Jeroen Kool
Publisher : Blackwell Verlag GmbH
Data Published : 18 March 2015
ISBN : 3527334645
EAN : 9783527334643
Format Book : PDF, Epub, DOCx, TXT
Number of Pages : 400 pages
Age + : 15 years
Language : English
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