Organic Stereochemistry PDF ePub eBook

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Organic Stereochemistry free pdf "This book should become an indispensable asset on the bookshelves of pharmaceutical laboratories in academia and in industry, as well as of laboratories devoted to plant protection. I am convinced that studying this book will be an eye-opener for many scientists in the field of life sciences. Furthermore, for teachers in this area it will not only be a useful compilation of the various languages and definitions of organic stereochemistry, but also a welcome source of examples for demonstrating to their students the intricate and intriguing role stereochemistry plays in the chemistry of life." - Prof. Dr. Dieter Seebach, Laboratory of Organic Chemistry, ETH Zurich, Switzerland This textbook presents the molecular scale of matter in the broad diversity and richness of its three dimensions, giving due attention when relevant to the temporal dimension in which molecules exist, act, and react. The focus is on two significant fields of three-dimensional chemistry: a presentation of the guiding principles in organic stereochemistry, followed by a focus on the biochemical and medicinal relevance of this discipline. The treatment of Guiding Principles gives priority to didactic clarity and nomenclature issues, as detailed and illustrated in Parts 1 to 4: 'Symmetry Elements and Operations, Classification of Stereoisomers' 'Stereoisomerism Resulting from One or Several Stereogenic Centers' 'Other Stereogenic Elements: Axes of Chirality, Planes of Chirality, Helicity, and (E,Z)-Diastereoisomerism' 'Isomerisms about Single Bonds and in Cyclic Systems' This is followed by Parts 5 to 8 which focus on the biomedicinal relevance of stereochemistry, with special reference to the biochemistry and pharmacology of medicinal compounds. Here, examples and applications are discussed and illustrated based on their relevance to a given specific stereochemical aspect: 'Chirality in Molecular and Clinical Pharmacology' 'The Conformational Factor in Molecular Pharmacology' 'The Concept of Substrate Stereoselectivity in Biochemistry and Xenobiotic Metabolism' 'Prostereoisomerism and the Concept of Product Stereoselectivity in Xenobiotic Metabolism' Finally, the book contains a gift for broad-minded readers with an interest in the historical roots of stereochemistry: 'Molecular Chirality in Chemistry and Biology: Historical Milestones' Key features: * Consists entirely of beautifully produced colored figures * Includes marginal notes, giving clear-cut short definitions of terms used in the corresponding caption * Provides an alphabetic glossary of terms * Offers an extensive index

About Bernard Testa

Bernard Testa is Emeritus Professor of the University of Lausanne, having served there for 25 years as a full professor of medicinal chemistry. He has written 6 books and edited 33 others, and (co)-authored well over 450 research and review articles in the fields of drug design and drug metabolism. Between 1994 and 1998, he was the European Editor of Pharmaceutical Research, and is now a Senior Editor of Chemistry

Details Book

Author : Bernard Testa
Publisher : Helvitica Chimica Acta Verlag,Switzerland
Data Published : 23 April 2014
ISBN : 3906390691
EAN : 9783906390697
Format Book : PDF, Epub, DOCx, TXT
Number of Pages : 400 pages
Age + : 15 years
Language : English
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