On the Production and Suppression of Muscular Twitchings and Hypersensitiveness of the Skin by Electrolytes PDF ePub eBook

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On the Production and Suppression of Muscular Twitchings and Hypersensitiveness of the Skin by Electrolytes free pdf Excerpt from On the Production and Suppression of Muscular Twitchings and Hypersensitiveness of the Skin by Electrolytes It has been shown in former publications that a slight variation in the proportion and character of the electrolytes in a tissue is capable of imparting to that tissue properties which it does not possess ordinarily, and it has been suggested that this fact might help us in recognizing the nature of a number of nervous and muscular diseases, and also possibly furnish a means of curing or mitigating them. This paper contains some further contributions to the same subject. It deals with the determination of electrolytes which are liable to produce and inhibit hyperactivity of muscles and hypersensitiveness of the nerves of the skin- and tries to answer the question whether or not the stimulating and inhibiting effects of ions are a function of their valency and electrical charge. I. The Production and Suppression of Muscular Twitchings by Electrolytes 1. Our muscles do not normally contract or twitch rhythmically, but they do so in certain diseases. The main electrolyte in our blood is sodium chloride. When we put a muscle into a pure sodium-chloride solution of the right osmotic pressure (i.e., isotonic with the muscle), the muscle soon begins to twitch, rhythmically, and these twitchings may last for several days, or about as long as the muscle lives. But when we add a very small, though definite, amount of a soluble calcium salt, the twitchings will not occur, though the muscle lives longer in such a solution than in a pure sodium-chloride solution. I concluded from this that we owe it to the calcium ions in the blood that our muscles do not twitch or beat rhythmically like our heart. To test this idea further, Mr. W. E. Garrey and I undertook, in 1899, a series of experiments, not yet published, on the behavior of muscles in solutions of sodium salts whose anions precipitate calcium. The muscle itself contains calcium salts, and we considered it likely that these calcium salts might help in preventing contractions. We therefore thought that by putting the muscle into solutions of sodium salts, which, by entering the muscle, precipitate the calcium contained in it, we might produce still more powerful rhythmical contractions than in a pure sodium-chloride solution. This was found to be true. In solutions of sodium-fluoride, -oxalate, -carbonate, -phosphate, etc., of the proper concentration (1 gram-molecule in 8 liters of the solution), we obtained similar, but more powerful, rhythmical contractions than in sodium-chloride solutions of the same osmotic pressure. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully- any imperfections that remain are intentionally left to preserve the state of such historical works.

About Jacques Loeb

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Details Book

Author : Jacques Loeb
Publisher : Forgotten Books
Data Published : 27 September 2015
ISBN : 1332092292
EAN : 9781332092291
Format Book : PDF, Epub, DOCx, TXT
Number of Pages : 28 pages
Age + : 15 years
Language : English
Rating :

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  • On the Production and Suppression of Muscular Twitchings and Hypersensitiveness of the Skin by Electrolytes free pdfOn the Production and Suppression of Muscular Twitchings and Hypersensitiveness of the Skin by Electrolytes

    Free Books Download ePub. Excerpt from On the Production and Suppression of Muscular Twitchings and Hypersensitiveness of the Skin by Electrolytes It has been shown in former publications that a sligh