Neurochemical Aspects of Neurotraumatic and Neurodegenerative Diseases PDF ePub eBook

Books Info:

Neurochemical Aspects of Neurotraumatic and Neurodegenerative Diseases free pdf Collectively, neurodegenerative diseases are characterized by chronic and progressive loss of neurons in discrete areas of the brain, producing debilitating symptoms such as dementia, loss of memory, loss of sensory or motor capability, decreased overall quality of life eventually leading to premature death. Two types of cell death are known to occur during neurodegeneration: (a) apoptosis and (b) necrosis. The necrosis is characterized by the passive cell swelling, intense mitochondrial damage with rapid loss of ATP, alterations in neural membrane permeability, high calcium influx, and disruption of ion homeostasis. This type of cell death leads to membrane lysis and release of intracellular components that induce inflammatory reactions. Necrotic cell death normally occurs at the core of injury site. In contrast, apoptosis is an active process in which caspases (a group of endoproteases with specificity for aspartate residues in protein) are stimulated. Apoptotic cell death is accompanied by cell shrinkage, dynamic membrane blebbing, chromatin condensation, DNA laddering, loss of phospholipids asymmetry, low ATP levels, and mild calcium overload. This type of cell death normally occurs in penumbral region at the ischemic injury site and in different regions in various neurodegenerative diseases.

About Akhlaq A. Farooqui

Dr. Akhlaq A. Farooqui is a leader in the field of brain phospholipases A2, bioactive ether lipid metabolism, polyunsaturated fatty acid metabolism, glycerophospholipid-, sphingolipid-, and cholesterol-derived lipid mediators, glutamate-induced neurotoxicity and neurological disorders. He has discovered the stimulation of plasmalogen-selective phospholipase A2 (PlsEtn-PLA2) in brains from patients with Alzheimer disease. Stimulation of PlsEtn-PLA2 produces plasmalogen deficiency and increases levels of eicosanoids that may be related to the loss of synapses, induction of neuroinflammation and oxidative stress in brains of patients with Alzheimer disease. Dr. Farooqui has published cutting edge research on the generation and identification of glycerophospholipid-, sphingolipid-, and cholesterol-derived lipid mediators in kainic acid neurotoxicity by lipidomics. He has previously authored five monographs: Glycerophospholipids in Brain: Phospholipase A2 in Neurological Disorders (2007)- Neurochemical Aspects of Excitotoxicity (2008)- Metabolism and Functions of Bioactive Ether Lipids in Brain (2008)- Hot Topics in Neural Membrane Lipidology (2009), and Beneficial Effects of Fish Oil on Human Brain (2009). All monographs are published by Springer. Dr. Farooqui has also edited two books: "Biogenic Amines: Pharmacological, Neurochemical and Molecular Aspects in the CNS" Nova Science Publishers, Hauppauge, N.Y (2010) and Molecular Aspects of Neurodegeneration and Neuroprotection, Bentham Science Publishers Ltd (2010).

Details Book

Author : Akhlaq A. Farooqui
Publisher : Springer-Verlag New York Inc.
Data Published : 22 November 2014
ISBN : 1489982566
EAN : 9781489982568
Format Book : PDF, Epub, DOCx, TXT
Number of Pages : 401 pages
Age + : 15 years
Language : English
Rating :

Reviews Neurochemical Aspects of Neurotraumatic and Neurodegenerative Diseases



17 Comments Add a comment




Related eBooks Download


  • Apoptosis free pdfApoptosis

    Apoptosis. or cell death. can be pathological. a sign of disease and damage. or physiological. a process essential for normal health. This pathological dysregulation of cell death can be characterized by either too much loss of essential cells in the heart..


  • Membrane Proteomics free pdfMembrane Proteomics

    The membranes surrounding cells and organelles constitute their interface with the local environment. The functions of membrane proteins include cell/cell and cell/extracellular matrix recognition..


  • Membrane Proteomics free pdfMembrane Proteomics

    The membranes surrounding cells and organelles constitute their interface with the local environment. The functions of membrane proteins include cell/cell and cell/extracellular matrix recognition..


  • Mitochondrial Signaling in Health and Disease free pdfMitochondrial Signaling in Health and Disease

    Mitochondria have traditionally been associated with metabolic functions- however recent research has uncovered a central role for these organelles in cell signaling. cell survival. and cell death. Mitochondrial dysfunction is a factor in a myriad of pathophysiological conditions..


  • Electric Cell-Substrate Impedance Sensing and Cancer Metastasis free pdfElectric Cell-Substrate Impedance Sensing and Cancer Metastasis

    Cell based impedance sensing is becoming a new biophysical and cellular technology in cell based analyses. The technology has been used in investigation of cellular growth and death. cell adhesion and migration..


  • Neurochemical Aspects of Neurotraumatic and Neurodegenerative Diseases free pdfNeurochemical Aspects of Neurotraumatic and Neurodegenerative Diseases

    . Collectively, neurodegenerative diseases are characterized by chronic and progressive loss of neurons in discrete areas of the brain, producing debilitating symptoms such as dementia, loss of memory