Discovering PDF ePub eBook

Books Info:

Discovering  free pdf This authoritative volume provides a contemporary view on the latest research in molecules with optimal drug-like properties. It is a valuable source to access current best practices as well as new research techniques and strategies. Written by leading scientists in their fields, the text consists of fourteen chapters with an underlying theme of early collaborative opportunities between pharmaceutical and discovery sciences. The book explores the practical realities of performing physical pharmaceutical and biopharmaceutical research in the context of drug discovery with short timelines and low compound availability. Chapters cover strategies and tactics to enable discovery as well as predictive approaches to establish, understand and communicate risks in early development. It also examines the detection, characterization, and assessment of risks on the solid state properties of advanced discovery and early development candidates, highlighting the link between solid state properties and critical development parameters such as solubility and stability. Final chapters center on techniques to improve molecular solubilization and prevent precipitation, with particularly emphasis on linking physiochemical properties of molecules to formulation selection in preclinical and clinical settings.

About Allen C Templeton

Dr. Allen C. Templeton is executive director of the Analytical Sciences organization within Merck Research Laboratories. He is responsible for the managing staff in the pursuit of scientific problem-solving for pharmaceutical product development. Before assuming his current position, Dr. Templeton held positions of increasing responsibility within Merck, including leadership roles in preformulation and formulation. Dr. Templeton earned his Ph.D. in analytical chemistry from the University of North Carolina at Chapel Hill. His research experience has been in the area of analytical and materials chemistry. He has published more than fifty articles, served as co-inventor on eleven patents and authored more than 120 presentations in the area of pharmaceutical analysis. He has organized a number of symposia and training courses on diverse topics within the field of pharmaceutical characterization. Dr. Templeton is an active member in a number of professional organizations, including the American Association of Pharmaceutical Scientists (AAPS) and the American Chemical Society (ACS). He has served in a number of roles for AAPS and is most recently the secretary/treasurer of the Physical Pharmacy and Biopharmaceutics section. He was elected to the United States Pharmacopeia (USP) expert committee on physical analysis and has worked to revise a number of USP standard chapters. He is also currently serving on the Analytical Leadership Group for the International Consortium for Innovation

Details Book

Author : Allen C Templeton
Publisher : Springer-Verlag New York Inc.
Data Published : 31 October 2014
ISBN : 1493913980
EAN : 9781493913985
Format Book : PDF, Epub, DOCx, TXT
Number of Pages : 511 pages
Age + : 15 years
Language : English
Rating :

Reviews Discovering



17 Comments Add a comment




Related eBooks Download


  • Predictive Approaches in Drug Discovery and Development free pdfPredictive Approaches in Drug Discovery and Development

    Practical Utility of Biomarkers in Drug Discovery and Development covers all aspects of biomarker research applied to drug discovery and development and contains state-of-the-art appraisals on the practical utility of genomic..


  • Computational Pharmaceutics free pdfComputational Pharmaceutics

    Molecular modeling techniques have been widely used in drug discovery fields for rational drug design and compound screening. Now these techniques are used to model or mimic the behavior of molecules..


  • Advanced Sensor and Detection Materials free pdfAdvanced Sensor and Detection Materials

    Presents a comprehensive and interdisciplinary review of the major cutting-edge technology research areas-especially those on new materials and methods as well as advanced structures and properties-for various sensor and detection devices The development of sensors and detectors at macroscopic or nanometric scale is the driving force stimulating research in sensing materials and technology for accurate detection in solid..


  • Development of Vaccines free pdfDevelopment of Vaccines

    Development of Vaccines: From Discovery to Clinical Testing outlines the critical steps. and analytical tools and techniques. needed to take a vaccine from discovery through a successful clinical trial..


  • Predictive ADMET free pdfPredictive ADMET

    By guiding in the application of techniques and tools for predicting ADMET outcomes in drug candidates. Predictive ADMET offers a road map for drug discovery scientists to generate effective and safe drugs for unmet medical needs..


  • Discovering  free pdfDiscovering

    . This authoritative volume provides a contemporary view on the latest research in molecules with optimal drug-like properties. It is a valuable source to access current best practices as well as new