Environmental Epigenomics in Health and Disease PDF ePub eBook

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Environmental Epigenomics in Health and Disease free pdf There are now compelling human epidemiological and animal experimental data that indicate the risk of developing adult-onset complex diseases and neurological disorders are influenced by persistent epigenetic adaptations in response to prenatal and early postnatal exposures to environmental factors. Epigenetics refers to heritable changes in gene function that occur without a change in the sequence of the DNA. The main components of the epigenetic code are DNA methylation, histone modifications, and non-coding RNAs. The epigenetic programs are established as stem cell differentiate during embryogenesis, and they are normally faithfully reproduced during mitosis. Moreover, they can also be maintained during meiosis, resulting in epigenetic transgenerational disease inheritance, and also potentially introducing phenotypic variation that is selected for in the evolution of new species. The objective of this book is to provide evidence that environmental exposures during early development can alter the risk of developing medical conditions, such as asthma, autism, cancer, cardiovascular disease, diabetes, obesity, and schizophrenia later in life by modifying the epigenome.

About Randy L. Jirtle

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Details Book

Author : Randy L. Jirtle
Publisher : Springer-Verlag Berlin and Heidelberg GmbH
Data Published : 17 May 2013
ISBN : 3642233791
EAN : 9783642233791
Format Book : PDF, Epub, DOCx, TXT
Number of Pages : 302 pages
Age + : 15 years
Language : English
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